Checkpoint64 has a preset for The Binding of Isaac: Rebirth: it already knows where the save folder is, backs it up automatically and keeps earlier versions. Everything this site has on The Binding of Isaac: Rebirth:
The Binding of Isaac: Rebirth
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Save file location
Windows:
%USERPROFILE%\Documents\My Games\Binding of Isaac Repentance+
macOS:~/Library/Application Support/Binding of Isaac Rebirth
Linux:~/.local/share/binding of isaac rebirth -
Sharing with friends
How to share your The Binding of Isaac: Rebirth world with friends, from playing live to taking turns when the host is offline.